SIRTActiv

SIRTActiv

WHAT IS?

logo_nutrigenomics-160x49

A REVOLUTION
IN THE WAY OF
LOSING WEIGHT

The first food supplement on the market, suitable for weight control, which brings togethe…The first food supplement on the market, suitable for weight control, which brings together a selected set of sirtuin activating nutrients.
atiradores de sirtuínas.

What are Sirtuins?

Recent advances in a new area of nutrition, nutrigenomics, allowed to identify a set of genes that, when activated, encode for the synthesis of certain proteins:

The sirtuínas (SIRT – Silent Information Regulation Transcript)

The sirtuins are responsible for a cascade of reactions at the level of human metabolism and longevity.

What are worth for?

Sirtuins play a key role, functioning as energy sensors and mediators of a vast array of physiological responses that have the purpose of survival. These responses include blocking fat storage, increasing stored fat burning, stimulating cellular repair and rejuvenation mechanisms, and increasing muscle mass.

For a more correct and complete evaluation of the results, the determination of % of body fat should be done,  and not just the determination of the decrease in body weight.Ask your pharmacist or nutritionist for advise.

SIRTActiv

HOW CAN WE ACTIVATE SIRTUINS?

The sirtuins can be induced through caloric restriction or physical exercise, but there is another alternative, which is the ingestion of certain nutrients present in foods that, when ingested, have the capacity to stimulate the production of sirtuins and to potentiate their action.

SIRTActiv

NUTRIENTS

The Power of Polyphenols

Polygon*

Polygonum cuspidatum Siebold
(min 90% resveratrol)

Vine*

Vitis vinifera L. var. tinctoria
(min 10% polyphenols)

Green tea*

Camellia sinensis Kuntze
(min 55% polyphenols, min 15% epigallocatechin gallate – EGCG)

Olive Tree*

Olea europaea L.
(min 6% oleuropein)

Turmeric*

Curcuma longa L.
(min 10% curcumin)

Leucine

Branched chain amino acid

*Extract

Learn more about these nutrients:

The polygon, Polygonum cuspidatum, also called Reynoutria japonica, is a plant native to Asia, distributed throughout North America and Europe, including Portugal. It is considered an invasive species in several countries. The roots of this plant are also the richest source of known resveratrol, being used in oriental medicine. [23]

Resveratrol was identified in 2003 as being a potent activator of sirtuins [24]. Studies in mice have clearly demonstrated health benefits, such as increased insulin sensitivity, increased glucose tolerance, decreased lipids in plasma and fat in the liver, suppression of inflammation and oxidative stress [25]. In man, decreased intrahepatic lipid content, glycemia, triglycerides, alanine aminotransferase, and markers of inflammation were observed. [26]

The vine is a plant native to Southern Europe and Western Asia, and has been cultivated for thousands of years by various civilizations in order to obtain wine.

It has medicinal properties and has been traditionally used in vascular diseases and as a venous tonic. [27]

Its leaves are rich in polyphenols: tannins, various flavonoids such as campferol, anthocyanidins, quercetin and resveratrol itself. The presence of different types of polyphenols, such as quercetin, increases the bioavailability of resveratrol and synergistically complements its effect, since resveratrol promotes the destruction of fat cells that already exist and quercetin prevents the formation of new fat cells . [28]

The high intake of green tea in Asia has been cited as the main reason for the "Asian paradox". Despite a high prevalence of smoking, Asia, and especially Japan, has the lowest rates of cardiovascular disease in the world. A high intake of green tea is linked to much lower rates of coronary heart disease. [29]

Dried leaves are very rich in polyphenols, such as chlorogenic, caffeic and gallic acid, as well as campferol, quercetin and myricetin (flavonoids). It also has another type of polyphenol, the epigallocatechin gallate - EGCG (catechin). [27]

The olive tree is a tree from the Mediterranean region, being much cultivated in Portugal and other Mediterranean countries, in order to obtain the olive oil.

In the leaves, among other substances, may be polyphenol oleuropein, as well as flavonoids such as apigenin, luteolin and rutin. The olive tree has traditionally been used in hypertension. Oleuropein showed antioxidant and hypoglycemic activity [27]. In addition to the direct activity of oleuropein as an activator of sirtuins [29], apigenin and rutin improve the absorption of quercetin (present in green tea), increasing its activity [31].

The health benefits of the Mediterranean diet, of which olive oil and moderately consumed wine are an important part, may in part be explained by the activation capacity of the sirtuins by the polyphenols found in these foods.

Curcuma, or saffron, is a spice widely used in traditional Indian cuisine and has been used in Ayurvedic medicine for more than 4000 years for its anti-inflammatory and healing properties. [29]

We know today that its properties are due to the presence of curcumin, a yellow pigment and at the same time a polyphenol that in recent studies has been observed to improve cholesterol levels, control blood sugar and reduce body inflammation [30]. These results are compatible with an activating action of the sirtuins.

Leucine is a branched-chain amino acid and is an essential amino acid, ie it is not capable of being synthesized in the human body and must be obtained through feed. It is essential to growth, stimulating the synthesis of proteins in muscles, helps stabilize and decrease blood glucose, by stimulating the release of insulin.

Studies have shown that the simultaneous presence of leucine and resveratrol results in a synergistic effect on the activation of sirtuins, producing an increase in their activity. In addition, it was further discovered that such synergy could be obtained not only with resveratrol, but also with other polyphenols such as hydroxycinnamic, cinnamic, or chlorogenic acid, which is also present in green tea. [32] Other studies have shown that leucine itself could directly activate the sirtuins [33]. The inclusion of leucine in the SIRTActiv formula is thus aimed at a synergistic and potentiating effect of the polyphenols.

Referências

1- Mead MN (2007). Nutrigenomics: the genome-food interface. Environmental Health Perspectives 115 (12): A582-A589.

2- Fenech M et al. (2011). Nutrigenetics and Nutrigenomics: Viewpoints on the Current Status and Applications in Nutrition Research and Practice. Journal of Nutrigenetics and Nutrigenomics 4: 69-89.

3-Li X (2013). SIRT1 and energy metabolism. Acta Biochim Biophys Sin 45: 51-60.

4- Park S et al. (2013). Do sirtuins promote mammalian longevity? A critical review on its relevance to the longevity effect induced by calorie restriction. Mol Cells 35 (6): 474-480.

5- Morris BJ (2013). Seven sirtuins for seven deadly diseases of age. Free Radic Biol Med 56: 133-171.

6- Cohen HY et al. (2004). Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science 305 (5682): 390-392.

7- Haigis MC and Guarente LP (2006). Mammalian sirtuins-emerging roles in physiology, aging and calorie restriction. Genes Dev 20: 2913-2921.

8- Radak Z et al. (2013). Redox-regulating sirtuins in aging, caloric restriction and exercise. Free Radic Biol Med 58: 87-97.

9- Michan S and Sinclair D (2007). Sirtuins in mammals: insights into their biological function. Biochem J 404 (1): 1-13.

10- Lee D and Goldberg AL (2013). SIRT1 protein, by blocking the activities of transcription factors FoxO1 and FoxO3, inhibits muscle atrophy and promotes muscle growth. J Biol Chem 288: 30515-30526.

11- Rathbone CR et al. (2009). SIRT1 increases skeletal muscle precursor cell proliferation. Eur J Cell Biol 88: 35-44.

12- Bordone L et al. (2006). SIRT1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells. PloS Biol 4 (2): 210-220.

13- Lee JH et al. (2009). Overexpression of SIRT1 protects pancreatic beta-cells against cytokine toxicity by suppressing the nuclear Factor-kappa B signaling pathway. Diabetes 58 (2): 344-351.

14- Houtkooper RH et al. (2012). Sirtuins as regulators of metabolism and health. Nat Rev Mol Cell Bio 13 (4): 225-238.

15- Purushotham A et al. (2009). Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation. Cell Metab 9 (4): 327-338.

16- Sequeira J et al. (2008). SIRT1-null mice develop an autoimmune-like condition. Exp Cell Res 314 (16): 3069-3074.

17- Gerhart-Hines Z et al. (2007). Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1 / PGC-1 alpha. Embo Journal 26 (7): 1913-1923.

18- Picard F et al. (2004). SIRT1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Nature 429 (6993): 771-776.

19- Satoh A et al. (2010). SIRT1 promotes the central adaptive response to diet restriction through activation of the dorsomedial and lateral nuclei of the hypothalamus. J Neurosci 30 (30): 10220-10232.

20- Hooper PL et al. (2010). Xenohormesis: health benefits from an eon of plant stress response evolution. Cell Stress Chaperones 15: 761-770.

21- Kennedy DO (2014). Polyphenols and the human brain: plant “secondary metabolite” ecologic roles and endogenous signaling functions drive benefits. Adv Nutr 5: 515-533.

22- Howitz KT and Sinclair DA (2008). Xenohormesis: sensing the chemical cues of other species. Cell 133: 387-391.

23- Soares T (2014). Sirtuínas – Artigo de revisão bibliográfica. Instituto de Ciências Biomédicas Abel Salazar. Repositório Aberto da Universidade do Porto.

24- Howitz KT et al. (2003). Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 425: 191-196.

25- Lagouge M et al. (2006). Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1 alpha. Cell 127 (6): 1109-1122.

26- Wong RHX et al. (2011). Acute resveratrol supplementation improves flow-mediated dilatation in overweight / obese individuals with mildly elevated blood pressure. Nutr Metab Cardiovas 21 (11): 851-856.

27- Cunha AP, Silva AP, Roque OR (2012). Plantas e Produtos Vegetais em Fitoterapia, 4ª Edição, Fundação Calouste Gulbenkian Serviço de Educação e Bolsas, 230-231, 508-509, 666-667.

28- Eseberri I et al. (2015). Doses of Quercetin in the Range of Serum Concentrations Exert Delipidating Effects in 3T3-L1 Preadipocytes by Acting on Different Stages of Adipogenesis, but Not in Mature Adipocytes. Oxid Med Cell Longev 2015: 480943.

29- Goggins A, Matten G (2015). A Dieta Sirt. Editora Lua de Papel – Leya, 50-57.

30- Panahi et al. (2015). Antioxidant and anti-inflammatory effects of curcuminoid-piperine combination in subjects with metabolic syndrome: A randomized controlled trial and an updated meta-analysis. Clin Nutr 34 (6): 1101-1108.

31- Scheepens A et al. (2010). Improving the oral bioavailability of beneficial polyphenols through designed synergies. Genes Nutr 5: 75-87.

32- Bruckbauer A et al. (2014). Synergistic effects of polyphenols and methylxanthines with Leucine on AMPK / Sirtuin-mediated metabolism in muscle cells and adypocites. PloS One 9: e89166.

33- Bruckbauer A et al. (2011). Effects of dairy consumption on SIRT1 and mitochondrial biogenesis in adipocytes and muscle cells. Nutr Metab (Lond) 8:91.

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